About TPGS

PROPERTIES OF TPGS

STABILITY AND SAFETY

MANUFACTURING

REGULATORY INFO

PHARMA/FOOD GRADE

STABILITY AND SAFETY OF TPGS

Stability
Vitamin E TPGS is a highly stable form of vitamin E because the labile and prone to oxidation hydroxyl group on the chroman ring of d-α-tocopherol is esterified. It is relatively stable when exposed to oxygen, heat, light, or oxidizing agents. It is unstable to alkali.

Vitamin E TPGS is stable when stored in a closed container at room temperature with a shelf life of 4 years when stored at room temperature in the original unopened container. TPGS is stable under the conditions of heat sterilization and repetitive heat/cool/cycles.
Heat Stability Stable up to approximately 199 °C
Flash Point 324 °C
Thermolysis Thermal Decomposition Temperature: No exotherm to 500 °C
Sterilization Stable when exposed to approximately 125 °C for 1 hour
Shelf Life 4 years (stored at room temperature in the original unopened container)
 
Safety
Vitamin E TPGS has a record of safety based on decades in animals and humans and on reported toxicology studies. Studies in humans included dosing of cholestatic children at doses of 25 IU/kg/day (equivalent to 64 mg TPGS/kg/day) for over two years. Please contact us for more information.

Vitamin E TPGS is also a safe compound for transportation, storage and handling. For more information please see the Material Safety Data Sheet (MSDS).
Oral LD-50 Higher than 7,000 mg/kg in rat (highest dose tested)
Dermal LD-50 ( rat) Higher than 2,000 mg/kg in rat (highest dose tested)
Skin Irritation None (guinea pig)
Eye Irritation Slight (rabbit)
Skin Sensitization None (guinea pig)


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