EMULSIFIER, SOLUBILIZER AND FORMULATION EXCIPIENT

Vitamin E TPGS has a molecular structure similar to an amphiphile with a polar hydrophilic head (polyethylene glycol 1000) and a lipophilic tail (phytyl chain of d-α-tocopherol). In addition, it exhibits low critical micellar concentration (CMC) and large surface area. These characteristics make it a good emulsifier. TPGS can emulsify or help solubilize a wide range of water-oil immiscible and other poorly soluble compounds.

The characteristics above coupled with its ability to form various liquid crystalline phases and its solubility and stability in water solutions make TPGS a useful formulation excipient.

The following are important characteristics of TPGS relevant to its functions as emulsifier, solubilizer and formulation excipient. More information on the properties of TPGS.
MeltingPoint 38 °C approximate (range 37-41)
SolubilityIn Water Soluble (up to 20 weight %)
HLB 13 (approximate hydrophile/lipophile balance)
CMC 0.02 weight % (Critical Micellar Concentration)
Particle Size Reported particle size diameter ranged from less than 1 and up to several microns for liquid emulsions and solid formulations with TPGS


The Antares Team — Your TPGS Partner in Product Innovation...