DIETARY SUPPLEMENTS
Vitamin E TPGS is an approved form of vitamin E and has been used to formulate supplements especially those designed to overcome malabsorption of vitamin E and other lipophilic nutrients and nutraceuticals.
Major advantages of vitamin E TPGS include.
- Supplies in water-soluble form the natural d-α-tocopherol which is universally accepted, including the Food and Drug Administration (FDA), the United States Pharmacopeia (USP) and the National Academy of Sciences (NAS) and industry, as more potent than the synthetic form dl-α-tocopherol. For more information on the advantages of the natural d-α- over the synthetic dl-α- tocopherol, please see reference 1 below.
- Overcomes malabsorption of vitamin E in malabsorbing patients. This benefit reported by Dr. Sokol in cholestatic patients more than 20 years ago was confirmed in multicenter clinical trial (reference 1 below).
- Enhances the absorption of other lipid soluble nutrients and natural compounds in malabsorbing patients (reference 2 below).
The major applications of vitamin E TPGS in dietary supplements include:
- Liquid vitamin E or liquid multivitamin/mineral supplements. As water soluble, TPGS is preferable over the oil forms of vitamin E especially in water based liquid products.
- Other forms of vitamin E or liquid multivitamin/mineral dietary supplements such as tablets, softgels, bars and others.
- Liquid and other supplements which aim to enhance absorption of lipophilic nutrients and natural compounds in malabsorbing populations.
For a summary of the TPGS vitamin E activity and other nutrient data which are useful in meeting the labeling requirements of the Food and Drug Administration (FDA) and other regulatory agencies in the United States and internationally please see the Nutrient Data Sheet.
Selected references
- Papas A. The Vitamin E Factor. HarperCollins Publishers. New York, 1999.
- Sokol RJ, Butler-Simon N, Conner C, Heubi JE, Sinatra FR, Suchy FJ, Heyman MB, Perrault J, Rothbaum RJ, Levy J, et al. Multicenter trial of d-alpha-tocopheryl polyethylene glycol 1000 succinate for treatment of vitamin E deficiency in children with chronic cholestasis. Gastroenterology. 1993 Jun;104(6):1727-35.
Argao EA, Heubi JE, Hollis BW, Tsang RC. d-Alpha-tocopheryl polyethylene glycol-1000 succinate enhances the absorption of vitamin D in chronic cholestatic liver disease of infancy and childhood. Pediatr Res. 1992 Feb;31(2):146-50.
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